Quarterly report pursuant to Section 13 or 15(d)

Notes and Loan Payable (Details Textual)

v3.10.0.1
Notes and Loan Payable (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 12, 2018
Aug. 14, 2018
May 14, 2018
Dec. 15, 2017
Oct. 09, 2018
Jul. 26, 2018
May 31, 2018
May 28, 2018
May 18, 2018
May 09, 2018
Jun. 15, 2017
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Oct. 31, 2018
Feb. 28, 2014
Mar. 31, 2012
Notes and Loans Payable [Line Items]                                      
Interest Expense                       $ 498,000 $ 1,440,000 $ 844,000 $ 4,637,000        
Loss Contingency, Damages Sought, Value                   $ 2,800,000                  
Gain (Loss) on Extinguishment of Debt               $ 181,000       0 (2,145,000) 181,000 (2,145,000)        
Proceeds From Convertible Notes Two                           2,007,000 0        
Warrants Not Settleable in Cash, Fair Value Disclosure     $ 91,000                                
Amortization of Debt Issuance Costs and Discounts             $ 865,000                        
Number of Warrant Issued     474,667                                
Class of Warrant or Right, Exercise Price of Warrants or Rights     $ 0.47                                
Liquidated Damages                       $ 0 0 $ 1,112,000 0        
Minimum Bid Price                       $ 1.00   $ 1.00          
Mandatory Default Amount Percentage on Principal                       40.00%   40.00%          
Deemed Dividend                       $ (5,541,000) $ 0 $ (11,140,000) 0        
Common Stock, Par or Stated Value Per Share                       $ 0.0001   $ 0.0001   $ 0.0001      
Debt Conversion, Original Debt, Amount                           $ 0 154,000        
Series E Warrants [Member]                                      
Notes and Loans Payable [Line Items]                                      
Warrant, Exercise Price, Decrease           $ 0.20                          
Deemed Dividend                       $ 572,000   572,000          
Series E Preferred Stock [Member]                                      
Notes and Loans Payable [Line Items]                                      
Preferred Stock, Convertible, Conversion Price, Decrease                 $ 0.30                    
Deemed Dividend                       $ 10,127,000   $ 10,127,000          
Maximum [Member]                                      
Notes and Loans Payable [Line Items]                                      
Class of Warrant or Right, Exercise Price of Warrants or Rights                       $ 200.00   $ 200.00   200.00      
Prepayment Premium Rate 35.00%                                    
Minimum [Member]                                      
Notes and Loans Payable [Line Items]                                      
Class of Warrant or Right, Exercise Price of Warrants or Rights                       $ 0.08   $ 0.08   $ 0.86      
Meda Pharma SARL [Member]                                      
Notes and Loans Payable [Line Items]                                      
Fixed Consideration Payable in Installments Over Three Year Period description                           In conjunction with the Asset Purchase Agreement with Meda described in Note 6, we agreed to pay a fixed consideration of $5.0 million, payable in installments over a three-year period as follows: (i) $1.5 million on the earlier of: (1) the successful transfer to us of all of the marketing authorizations for the product or (2) the date which is six months after the Completion Date (as defined in the Asset Purchase Agreement); (ii) $1.5 million on the first anniversary of the Completion Date; (iii) $1.0 million on the second anniversary of the Completion Date; and (iv) $1.0 million on the third anniversary of the Completion Date.          
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Long-term Debt                       $ 3,700,000   $ 3,700,000          
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Noncurrent Liabilities, Long-term Debt                       900,000   900,000          
Payments for Asset Purchase Agreement Amount       $ 1,500,000             $ 1,500,000                
Debt Instrument, Interest Rate, Stated Percentage                     15.00%                
Mablife Notes Payable [Member]                                      
Notes and Loans Payable [Line Items]                                      
Notes Payable                               $ 100,000      
Interest Expense                           0 $ 0        
Loss Contingency, Damages Sought, Value                               $ 205,000      
Asset Acquisition Payable [Member]                                      
Notes and Loans Payable [Line Items]                                      
Interest Expense                           195,000          
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Long-term Debt                       3,000,000   3,000,000          
Convertible Notes Two [Member]                                      
Notes and Loans Payable [Line Items]                                      
Debt Instrument, Face Amount     $ 2,781,000                                
Debt Instrument, Unamortized Discount     $ 556,000                                
Proceeds From Convertible Notes Two               $ 2,007,000                      
Debt Instrument Unamortized Discount Percentage     20.00%                                
Debt InstrumentPlacement Agent Fee Percentage             8.00%                        
Placement Agent Fee             $ 178,000                        
Other Placement Agent Fee             $ 40,000                        
Debt Instrument, Convertible, Conversion Price   $ 0.0759 $ 0.375                                
Debt Conversion Converted Instrument Maximum Shares to be Issued     6,397,456                                
Debt Instrument, Maturity Date, Description     The May 2018 Convertible Notes are due and payable upon the earlier of (a) November 18, 2018 and (b) the closing of one or more subsequent financings with gross proceeds equal to at least $3,000,000 in the aggregate. The holders of the May 2018 Convertible Notes have the option to extend the maturity date of the notes through February 18, 2019. The May 2018 Convertible Notes represent senior indebtedness of the Company.                                
Interest Expense, Debt                       $ 433,000   $ 649,000          
Debt Instrument, Interest Rate, Stated Percentage             1.50%         19.99%   19.99%          
Liquidated Damages                           $ 1,112,000          
Debt Instrument Debt Default Percentage             140.00%                        
Debt Conversion, Original Debt, Amount   $ 175                                  
Convertible Notes Five [Member]                                      
Notes and Loans Payable [Line Items]                                      
Debt Instrument, Face Amount $ 103,000                                    
Debt Instrument, Interest Rate, Stated Percentage 12.00%                                    
Debt Instrument, Maturity Date Sep. 11, 2019                                    
Common Stock, Par or Stated Value Per Share                       $ 0.0001   $ 0.0001          
Debt Instrument Convertible Conversion Price Description                           conversion price equal to sixty-one percent (61%) of the average of the lowest two closing bid prices of our common stock during the twenty (20) trading days immediately preceding conversion          
Debt Conversion Converted Instrument Shares Issued Description                           The number of shares issuable upon any conversion is limited to 4.99% of our then issued and outstanding common stock.          
Debt Default Interest Rate 22.00%                                    
Convertible Notes Five [Member] | Minimum [Member]                                      
Notes and Loans Payable [Line Items]                                      
Prepayment Premium Rate 15.00%                                    
Mablife [Member]                                      
Notes and Loans Payable [Line Items]                                      
Loans Payable                                     $ 600,000
Royalty Rate Percent of Net Sales                                     0.60%
Purchase Obligation, Due in Fourth Year                                   $ 25,000  
Purchase Obligation, Due in Fifth Year                                   35,000  
Mablife [Member] | Secondary Patent Rights [Member]                                      
Notes and Loans Payable [Line Items]                                      
Purchase Obligation, Due in Second Year                                   15,000  
Purchase Obligation, Due in Third Year                                   25,000  
Purchase Obligation                                   $ 150,000  
Subsequent Event [Member]                                      
Notes and Loans Payable [Line Items]                                      
Amendment Fees         $ 49,220                            
Subsequent Event [Member] | Convertible Notes Five [Member]                                      
Notes and Loans Payable [Line Items]                                      
Prepayment Premium Rate                                 20.00%